eLife3h
Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language
Recent research has used large language models (LLMs) to study the neural basis of naturalistic language processing in the human brain. LLMs have rapidly grown in complexity, leading to improved ...
eLife3h
Membrane potential modulates ERK activity and cell proliferation
Department of Physiology, Division of Life Science, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan ...
eLife5h
Publishing with eLife: “authors have a lot of control in the publication process”
What do authors think about publishing in eLife’s model? We spoke with Meike van der Heijden to find out about her experience.
eLife1d
Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions
Two-photon (2P) fluorescence imaging through gradient index (GRIN) lens-based endoscopes is fundamental to investigate the functional properties of neural populations in deep brain circuits. However, ...
eLife1d
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing
Endocrine Neoplasia Translational Research Center, Division of Endocrinology, Diabetes and Metabolism, Chaim Sheba Medical Center, and Tel Aviv University Faculty of Medicine, Ramat Gan, Israel This ...
eLife1d
Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma
The study is a valuable addition to the field, showing how particulate matter may be acting via nociceptor neurons towards neutrophilic asthma exacerbations. The solid evidence for the role of a ...
eLife1d
Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans
Membrane proteins are sorted to the plasma membrane (PM) via Golgi-dependent trafficking. However, our recent studies challenged the essentiality of Golgi in the biogenesis of specific transporters.
eLife1d
Decisions: Tracking the evolution of a single choice
Measuring the activity of hundreds of neurons in macaque brains simultaneously provides further evidence that drift-diffusion dynamics underlie how decisions are made in the brain.
eLife7d
Reconstructing the evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene
Series of paleomaps visualising the geographical and chronological aspects of the main events during the evolutionary history of the freshwater fish family Nemacheilidae across Eurasia. A red star ...
eLife4d
Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model
Pancreatic cancer-associated muscle atrophy is characterized by strong mitochondrial metabolic defects that are not limited to carbohydrate, protein, and redox metabolism, but also concern lipid and ...
eLife11d
Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos
This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...
eLife8d
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...